Ddit4 hif1a
WebDDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the stress such as chemother- ... HIF, ATF4, and miR-221. Thirdly, the function changed in many tumor related cells including adipocytes, immune cells, and muscle cells via the up ... WebNov 24, 2010 · mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α Mol Cell. 2010 Nov 24;40(4):509-20. doi: 10.1016/j.molcel.2010.10.030. ... Ddit4 protein, mouse Hypoxia-Inducible Factor 1, alpha Subunit Multiprotein Complexes Proteins ...
Ddit4 hif1a
Did you know?
WebFeb 12, 2024 · DNA damage-inducible transcript 4 (DDIT4) is a protein induced by hypoxia and in response to DNA stress. Mechanistically, DDIT4 inhibits mammalian target of … WebMay 5, 2024 · Intriguingly, in hypoxia, DDIT4 transcription is induced by HIF-1α , but Ip et al. allude that IL-10-induced expression of this factor is HIF-1α-independent. Therefore, it is …
WebNov 23, 2016 · Further we demonstrated that DDIT4 exert these effects down-stream to HIF1α. Our findings provide an insight in regulation of adult stem cells homeostasis by … WebFeb 14, 2024 · Orthologous to human DDIT4 (DNA damage inducible transcript 4). [provided by Alliance of Genome Resources, Apr 2024] Other designations. DNA damage-inducible transcript 4 protein, HIF-1 responsive RTP801, HIF-1 responsive protein RTP801, REDD-1, dexamethasone-induced gene 2 protein, protein regulated in development and DNA …
WebMar 21, 2024 · Entrez Gene Summary for DDIT4 Gene. Predicted to enable 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of TOR … Clinical interest in DDIT4 is based primarily on its effect on mTOR, which has been associated with aging and linked with diseases such as tuberous sclerosis, lymphangioleiomyomatosis, diabetes, and cancer. In particular, the overactivation of mTOR in many cancer types has led to the development of mTOR inhibitors for cancer treatment. DDIT4 has begun to receive attention in this regard via the diabetes drug Metformin which has been shown to reduce cancer risk and incr…
WebIn therapeutic studies, supplementation with LPA or the autophagy inducer rapamycin significantly promotes dMφ autophagy and cell residence, and improves embryo resorption in Enpp2 ± and spontaneous abortion mouse models, which should be dependent on the activation of DDIT4-autophagy-CLDN7-adhesion molecules axis. This observation …
WebXiaoyu Deng is an academic researcher from Zhengzhou University. The author has contributed to research in topic(s): Nasopharyngeal carcinoma & DDIT4. The author has co-authored 2 publication(s). swap nectar points for vouchersWebNext we determined whether DDIT4 acts as a downstream regulator of the main regulator of hypoxic responses, HIF1α . siRNA knock-down of either HIF1α or DDIT4 completely reversed the stimulatory... swap near to ethWebDec 2, 2024 · DDIT4 played crucial roles in the differentiation of CAFs and T cells. Collectively, this study demonstrates that DDIT4 contributes a critical role in HNSCC progression. The positive feedback regulation between DDIT4 and HIF-1a may be a potential target for HNSCC treatment. Keywords: DDIT4; HNSCC; ferroptosis; hypoxia; … ski resorts historic usaWebApr 4, 2024 · DDIT4 was initially identified as a hypoxia-regulated HIF-1 target gene. Its strong upregulation by hypoxia was detected both in vitro and in an animal model of ischemic stroke [ 13 ]. High DDIT4 expression is associated with a poor prognosis in multiple cancer types [ 14, 15, 16, 17 ]. swap neighbor char in stringWebMar 17, 2024 · Current research supported oxygen sensing is a complex signal network, and the study of hypoxia-related protein DDIT4 was a potential visitor in the oxygen sensing … ski resorts high altitude europeWebOur results show that significant reduction of proliferative activity of MSCs is observed after 20 passages (~50 cell generations). Regardless of the oxygen, in senescent cells PKM2, SERPINE1, and VEGFA were upregulated while ANKRD37, DDIT4, HIF1A, and TXNIP were downregulated. ski resorts hailey idWebNov 23, 2016 · DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling. November 2016; Scientific Reports 6(1) ... NF-κB, p63, and HIF-1 [39]. ..... Low passage … ski resorts historic us